beta-Catenin [p Ser33, p Ser37] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24456

Novus Biologicals, part of Bio-Techne
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NBP2-24456
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all beta-Catenin Antibodies »

Product Specifications

Immunogen

A portion of human Beta-catenin protein containing phosphorylated serine residues at position 33 and 37 was used as the immunogen for this phospho antibody.

Modification

p Ser33, p Ser37

Marker

Epithelial Cell Marker, Adherens Junction Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for beta-Catenin [p Ser33, p Ser37] Antibody

Western Blot: beta-Catenin [p Ser33, p Ser37] Antibody [NBP2-24456]

Western Blot: beta-Catenin [p Ser33, p Ser37] Antibody [NBP2-24456]

Western Blot: beta-Catenin [p Ser37, p Ser33] Antibody [NBP2-24456] - Analysis of Beta-catenin (Ser33/Ser37) in recombinant fusion protein containing 1) phosphorylated serine residues at positions 33 and 37 and 2) unphosphorylated serine residues at positions 33 and 37, using beta catenin phospho antibody at 0.25 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for beta-Catenin [p Ser33, p Ser37] Antibody

Application
Recommended Usage

Western Blot

0.25-1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.1 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: beta-Catenin

The protein encoded by the beta Catenin gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs arenecessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion betweencells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contactinhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this proteinbinds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this geneare a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Alternate Names

bCatenin, CTNNB1

Gene Symbol

CTNNB1

UniProt

P35222

Additional beta-Catenin Products

Product Documents for beta-Catenin [p Ser33, p Ser37] Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for beta-Catenin [p Ser33, p Ser37] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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