BMPR-IB/ALK-6 Antibody (2F3)

Novus Biologicals, part of Bio-Techne | Catalog # H00000658-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Knockdown Validated, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 2F3

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all BMPR-IB/ALK-6 Antibodies »

Product Specifications

Immunogen

BMPR1B (AAH47773, 14 a.a. ~ 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTFAKMSESQDIKL

Specificity

BMPR1B - bone morphogenetic protein receptor, type IB

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for BMPR-IB/ALK-6 Antibody (2F3)

Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]

Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]

Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01] - Analysis of BMPR1B expression in transfected 293T cell line by BMPR1B monoclonal antibody (M01), clone 2F3.Lane 1: BMPR1B transfected lysate(56.9 KDa).Lane 2: Non-transfected lysate.
Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]

Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01]

Western Blot: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01] - Analysis of BMPR1B over-expressed 293 cell line, cotransfected with BMPR1B Validated Chimera RNAi ( Cat # H00000658-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with BMPR1B monoclonal antibody (M01) clone 2F3 (Cat # H00000658-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Sandwich ELISA: BMPR-IB/ALK-6 Antibody (2F3) [H00000658-M01] - Detection limit for recombinant GST tagged BMPR1B is approximately 0.1ng/ml as a capture antibody.

Applications for BMPR-IB/ALK-6 Antibody (2F3)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against recombinant protein for WB. It has been used for RNAi Validation and ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: BMPR-IB/ALK-6

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Long Name

Bone Morphogenetic Protein Receptor IB

Alternate Names

ALK-6, BMPR1B, BMPRIB, CDw293

Entrez Gene IDs

658 (Human)

Gene Symbol

BMPR1B

OMIM

112600 (Human)

UniProt

AAH47773 (Human)

Additional BMPR-IB/ALK-6 Products

Product Documents for BMPR-IB/ALK-6 Antibody (2F3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BMPR-IB/ALK-6 Antibody (2F3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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