BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.

Long Name

Breast Cancer 2

Alternate Names

BRCA1/BRCA2-containing complex, subunit 2, BRCC2, breast and ovarian cancer susceptibility gene, early onset, breast cancer 2 tumor suppressor, breast cancer 2, early onset, breast cancer susceptibility protein BRCA2, breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1Fanconi anemia, complementation group D1, Fanconi anemia group D1 protein, GLM3, PNCA2

Gene Symbol

BRCA2

Additional BRCA2 Products

Product Documents for BRCA2 Antibody (BRCA2/2158) [Janelia Fluor® 646]

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Product Specific Notices for BRCA2 Antibody (BRCA2/2158) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BRCA2 Antibody (BRCA2/2158) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24027JF646

Key Product Details

Species Reactivity

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Applications for BRCA2 Antibody (BRCA2/2158) [Janelia Fluor® 646]

Immunohistochemistry-Paraffin

Formulation, Preparation, and Storage

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Background: BRCA2