Caldesmon/CALD1 Antibody (CALD1/820 + h-CALD) [Alexa Fluor® 647]

Validated:

Alexa Fluor 647 (Excitation = 650 nm, Emission = 668 nm)

Monoclonal Mouse IgG1 Kappa/IgG1 Kappa Clone # CALD1/820 + h-CALD

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant full-length human Caldesmon/CALD1 protein (Caldesmon/CALD1/820); Crude human uterus extract (h-CALD) (Uniprot: Q05682)

Cytoplasmic

Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120'150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70'80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This monoclonal antibody recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

Smooth Muscle Marker

Monoclonal

Mouse

IgG1 Kappa/IgG1 Kappa

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.