Clusterin/APOJ Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90128

Novus Biologicals, part of Bio-Techne
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NBP1-90128
NBP1-90128-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Clusterin Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS

Reactivity Notes

Reactivity reported in scientific literature (PMID:16524965).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Clusterin/APOJ Antibody

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128] - Staining in human epididymis and skeletal muscle tissues using anti-CLU antibody. Corresponding CLU RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128] - Staining of human skeletal muscle shows low expression as expected.
Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128]

Immunohistochemistry-Paraffin: Clusterin/APOJ Antibody [NBP1-90128] - Staining of human epididymis shows high expression.

Applications for Clusterin/APOJ Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Clusterin

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid poly-peptide that is posttranslationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, alpha and beta, are associated through disulfide bonds. The beta subunit (also called ApoJalpha) corresponds to residues 23-227. The alpha subunit (also called ApoJbeta) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences beta-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer's disease pathogenesis.

Alternate Names

APOJ, CLI, CLU, SGP-2, SP-40, TRPM-2

Gene Symbol

CLU

Additional Clusterin Products

Product Documents for Clusterin/APOJ Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Clusterin/APOJ Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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