Cytokeratin 17 Antibody (KRT17/8320R)

Unconjugated

Recombinant Monoclonal Rabbit IgG Kappa Clone # KRT17/8320R

0.2 mg/ml

Recombinant fragment of human Cytokeratin 17 protein (exact sequence is proprietary)

Cytoplasm.

Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation CK17 is expressed in SCLC much higher than in LADC Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17 Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype

Monoclonal

Rabbit

IgG Kappa

Positive Controls: T24 cells. Human skin, bladder or cervix.

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.

Protein A or G purified

10mM PBS with 0.05% BSA

0.05% Sodium Azide

0.2 mg/ml

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C. Do not freeze.