Cytokeratin 17 Antibody (KRT17/8320R) [CoraFluor™ 1]

CoraFluor 1

Recombinant Monoclonal Rabbit IgG Kappa Clone # KRT17/8320R

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant fragment of human Cytokeratin 17 protein (exact sequence is proprietary)

Cytoplasm.

Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation CK17 is expressed in SCLC much higher than in LADC Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17 Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype

Monoclonal

Rabbit

IgG Kappa

CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.

Protein A or G purified

PBS

No Preservative

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark. Do not freeze.