DAP3 Antibody (42C617.1.2) - Azide Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33222

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # 42C617.1.2

Format

Azide Free

Concentration

0.5 mg/ml

View all DAP3 Antibodies »

Product Summary for DAP3 Antibody (42C617.1.2) - Azide Free

Immunogen

The antibody was raised against a synthetic peptide corresponding to amino acids 51-66 of human DAP-3 protein.

Reactivity Notes

75% sequence identity with rat protein.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for DAP3 Antibody (42C617.1.2) - Azide Free

Western Blot: DAP3 Antibody (42C617.1.2)Azide Free [NBP2-33222]

Western Blot: DAP3 Antibody (42C617.1.2)Azide Free [NBP2-33222]

Western Blot: DAP3 Antibody (42C617.1.2) - Azide Free [NBP2-33222] - Analysis of DAP-3 in A) human brain, B) Jurkat and C) NIH 3T3 lysate using this antibody at 5 ug/ml. Image from the standard format of this antibody.

Applications for DAP3 Antibody (42C617.1.2) - Azide Free

Application
Recommended Usage

Western Blot

3-5 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin. Does not contain BSA.

Format

Azide Free

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DAP3

Death Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-gamma and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions.

Alternate Names

bMRP-10, DAP-3Death-associated protein 3, death associated protein 3, DKFZp686G12159,28S ribosomal protein S29, mitochondrial, FLJ12817, MGC126058, MGC126059, mitochondrial 28S ribosomal protein S29, MRP-S29Ionizing radiation resistance conferring protein, MRPS29S29mt

Gene Symbol

DAP3

Additional DAP3 Products

Product Documents for DAP3 Antibody (42C617.1.2) - Azide Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DAP3 Antibody (42C617.1.2) - Azide Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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