DUOX1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-93521

Novus Biologicals, part of Bio-Techne
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NB100-93521
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all DUOX1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence EKFQRSCLHQTVQ corresponding to internal region according to NP_059130.2 , NP_787954.1.

Epitope

EKFQRSCLHQTVQ

Specificity

This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical;

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for DUOX1 Antibody

Immunohistochemistry-Paraffin: DUOX1 Antibody [NB100-93521]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NB100-93521]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NB100-93521] - Staining of Human Thyroid Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Applications for DUOX1 Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 6 ug/ml

Immunohistochemistry-Paraffin

4 - 6 ug/ml

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: Preliminary experiments in human placenta and thyroid gland lysates gave no specific signal but low background. IHC-P: Human thyroid shows staining of membranes in epithelial cells of the gland. WB reactivity reported in (PMID: 27526200).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 3 using NB100-93521 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DUOX1

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Alternate Names

dual oxidase 1, DUOX, EC 1.11.1.-, EC 1.6.3.1, Large NOX 1, LNOX1flavoprotein NADPH oxidase, Long NOX 1, MGC138840, NADPH thyroid oxidase 1, nicotinamide adenine dinucleotide phosphate oxidase, NOXEF1, THOX1MGC138841, Thyroid oxidase 1

Entrez Gene IDs

53905 (Human)

Gene Symbol

DUOX1

UniProt

NP_059130.2 (Human)

Additional DUOX1 Products

Product Documents for DUOX1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DUOX1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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