ERManI Antibody (3C2) [DyLight 650]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-13167C

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP2-13167

Alexa Fluor 350

NBP2-13167AF350

Alexa Fluor 405

NBP2-13167AF405

Alexa Fluor 488

NBP2-13167AF488

Alexa Fluor 532

NBP2-13167AF532

Alexa Fluor 594

NBP2-13167AF594

Alexa Fluor 647

NBP2-13167AF647

Alexa Fluor 700

NBP2-13167AF700

Alexa Fluor 750

NBP2-13167AF750

Allophycocyanin

NBP2-13167APC

Biotin

NBP2-13167B

CoraFluor 1

NBP2-13167CL1

DyLight 350

NBP2-13167UV

DyLight 405

NBP2-13167V

DyLight 488

NBP2-13167G

DyLight 550

NBP2-13167R

DyLight 594

NBP2-13167DL594

DyLight 680

NBP2-13167FR

DyLight 755

NBP2-13167IR

FITC

NBP2-13167F

HRP

NBP2-13167H

Janelia Fluor 525

NBP2-13167JF525

Janelia Fluor 549

NBP2-13167JF549

Janelia Fluor 585

NBP2-13167JF585

Janelia Fluor 635

NBP2-13167JF635

Janelia Fluor 646

NBP2-13167JF646

Janelia Fluor 669

NBP2-13167JF669

mFluor Violet 450 SE

NBP2-13167MFV450

mFluor Violet 500 SE

NBP2-13167MFV500

mFluor Violet 610 SE

NBP2-13167MFV610

PE

NBP2-13167PE

PerCP

NBP2-13167PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-80726

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse (Negative)

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockout Validated, Western Blot

Label

DyLight 650 (Excitation = 652 nm, Emission = 672 nm)

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # 3C2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ERManI Antibodies »

Product Specifications

Immunogen

Full length human recombinant ERManI [Swiss-Prot# Q9UKM7]

Reactivity Notes

Does not react with mouse.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Applications for ERManI Antibody (3C2) [DyLight 650]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ERManI

ERManI, also known as endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase or MAN1B1, is a putative ER resident mannosidase that plays a rate-limiting role in generating a signal that targets misfolded N-linked glycoproteins for ER-associated degradation (ERAD). ERManI codes for an enzyme that converts Man9GlcNAc to Man8GlcNAc isomer B during N-glycan biosynthesis. It also facilitates the trimming of Man5-6GlcNAc2 in the endoplasmic reticulum associated degradation pathway. Multiple transcript variants of ERManI can result from alternative splicing, and a related pseudogene can be found on chromosome 11. Research has found that mutations on the ERManI gene can result in autosomal-recessive intellectual disabilities and developmental delays (PMID: 21763484). ERManI is predominately localized to the Golgi and endoplasmic reticulum.

Alternate Names

alpha 1,2-mannosidase, EC 3.2.1.113, endoplasmic reticulum alpha-mannosidase 1, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1, ER alpha 1,2-mannosidase, ER alpha-1,2-mannosidase, ER ManI, ER mannosidase 1, ERMan1, Man9GlcNAc2-specific processing alpha-mannosidase, Man9GlcNAc2-specific-processing alpha-mannosidase, MANA-ER, Mannosidase alpha class 1B member 1, mannosidase, alpha, class 1B, member 1, MRT15, RP11-350O14.2

Gene Symbol

MAN1B1

Additional ERManI Products

Product Documents for ERManI Antibody (3C2) [DyLight 650]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for ERManI Antibody (3C2) [DyLight 650]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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