The GDF5 gene is involved in skeletal development through bone and cartilage formation. This gene encodes for a 501 amino acid long, 55 kDA protein that is part of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily which is known to regulate cell growth and differentiation in embryotic and adult tissues. The GDF5 gene is involved in paxillian interactions, mitochondrial apoptosis, the cytokine-cytokine receptor interaction, and the TGF-beta signaling pathway through interacting with other genes such as BMPR1A, BMPR1B, BMPR2, HTRA1, and CHRDL2. The GDF5 gene has been associated to chondrodysplasia, synostosis, periostitis, short stature, cushing's symphalangism, brachydactyly and ankylosis.

Long Name

Growth Differentiation Factor 5

Alternate Names

BMP-14, CDMP-1, GDF5

Gene Symbol

GDF5

Additional GDF-5/BMP-14 Products

Product Documents for GDF-5/BMP-14 Antibody (RM0242-13J15) [Janelia Fluor® 646]

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Product Specific Notices for GDF-5/BMP-14 Antibody (RM0242-13J15) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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GDF-5/BMP-14 Antibody (RM0242-13J15) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-12333JF646

Key Product Details

Species Reactivity

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Product Summary for GDF-5/BMP-14 Antibody (RM0242-13J15) [Janelia Fluor® 646]

Immunogen

Reactivity Notes

Clonality

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Isotype

Applications for GDF-5/BMP-14 Antibody (RM0242-13J15) [Janelia Fluor® 646]

Block/Neutralize

Western Blot

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Background: GDF-5/BMP-14