GDF-5/BMP-14 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-88575

Novus Biologicals, part of Bio-Techne
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NBP1-88575
NBP1-88575-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GDF-5/BMP-14 Antibodies »

Product Summary for GDF-5/BMP-14 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RYVFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GDF-5/BMP-14 Antibody

Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575]

Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575]

Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)
Immunohistochemistry-Paraffin: GDF-5/BMP-14 Antibody [NBP1-88575]

Immunohistochemistry-Paraffin: GDF-5/BMP-14 Antibody [NBP1-88575]

Immunohistochemistry-Paraffin: GDF-5/BMP-14 Antibody [NBP1-88575] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.
Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575]

Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575]

Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-236

Applications for GDF-5/BMP-14 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GDF-5/BMP-14

The GDF5 gene is involved in skeletal development through bone and cartilage formation. This gene encodes for a 501 amino acid long, 55 kDA protein that is part of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily which is known to regulate cell growth and differentiation in embryotic and adult tissues. The GDF5 gene is involved in paxillian interactions, mitochondrial apoptosis, the cytokine-cytokine receptor interaction, and the TGF-beta signaling pathway through interacting with other genes such as BMPR1A, BMPR1B, BMPR2, HTRA1, and CHRDL2. The GDF5 gene has been associated to chondrodysplasia, synostosis, periostitis, short stature, cushing's symphalangism, brachydactyly and ankylosis.

Long Name

Growth Differentiation Factor 5

Alternate Names

BMP-14, CDMP-1, GDF5

Gene Symbol

GDF5

Additional GDF-5/BMP-14 Products

Product Documents for GDF-5/BMP-14 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GDF-5/BMP-14 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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