Gelsolin/GSN Antibody (20) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-05161JF646

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-05161AF350

Alexa Fluor 532

NBP1-05161AF532

Alexa Fluor 594

NBP1-05161AF594

Alexa Fluor 750

NBP1-05161AF750

CoraFluor 1

NBP1-05161CL1

DyLight 594

NBP1-05161DL594

Janelia Fluor 525

NBP1-05161JF525

Janelia Fluor 549

NBP1-05161JF549

Janelia Fluor 669

NBP1-05161JF669

mFluor Violet 450 SE

NBP1-05161MFV450

mFluor Violet 500 SE

NBP1-05161MFV500

mFluor Violet 610 SE

NBP1-05161MFV610

Forumulation

Catalog #

BSA Free

NBP1-05161

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Janelia Fluor 646

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # 20

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Gelsolin/GSN Antibodies »

Product Specifications

Immunogen

Gelsolin purified from human plasma

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Applications for Gelsolin/GSN Antibody (20) [Janelia Fluor® 646]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Gelsolin/GSN

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

Alternate Names

ADF, AGEL, Brevin, GSN

Gene Symbol

GSN

Additional Gelsolin/GSN Products

Product Documents for Gelsolin/GSN Antibody (20) [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Gelsolin/GSN Antibody (20) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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