GLP-1R Antibody (7H7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26551

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # 7H7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GLP-1R Antibodies »

Product Specifications

Immunogen

Recombinant Human GLP-1R protein [UniProt P43220]

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Scientific Data Images for GLP-1R Antibody (7H7)

GLP-1R Antibody (7H7)

ELISA: GLP-1R Antibody (7H7) [NBP3-26551] -

ELISA: GLP-1R Antibody (7H7) [NBP3-26551] - The Binding Activity of GLP-1R with GLP-1R Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP-1R at 2 ug/mL can bind GLP-1R Antibody, the EC50 is 54.54-94.23 ng/mL.

Applications for GLP-1R Antibody (7H7)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50% Glycerol, 0.01M PBS, PH 7.4

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: GLP-1R

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Long Name

Glucagon-like Peptide 1 Receptor

Alternate Names

GLP1R

Gene Symbol

GLP1R

Additional GLP-1R Products

Product Documents for GLP-1R Antibody (7H7)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GLP-1R Antibody (7H7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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