GLP-1R Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14335

Novus Biologicals, part of Bio-Techne
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NBP3-14335
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (94%), Hamster (94%), Mouse (94%), Primate (100%), Rabbit (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all GLP-1R Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human GLP-1R.

Epitope

N-Terminus

Reactivity Notes

Expected reactivity based on percent sequence identity: Rat, Canine, Bat (88%)

Specificity

Human GLP-1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for GLP-1R Antibody

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human ovary carcinoma after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human pancreas
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335]

Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human adrenal, pheochromocytoma, after heat-induced antigen retrieval.
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Applications for GLP-1R Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: GLP-1R

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Long Name

Glucagon-like Peptide 1 Receptor

Alternate Names

GLP1R

Gene Symbol

GLP1R

Additional GLP-1R Products

Product Documents for GLP-1R Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for GLP-1R Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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