gp130/CD130 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-15776

Novus Biologicals, part of Bio-Techne
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NBP2-15776
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Human

Predicted:

Canine (94%), Mouse (91%), Porcine (95%), Rhesus Macaque (98%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all gp130 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human gp130/CD130. The exact sequence is proprietary.

Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein; Isoform 2: Secreted

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

104 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for gp130/CD130 Antibody

Western Blot: gp130/CD130 Antibody [NBP2-15776]

Western Blot: gp130/CD130 Antibody [NBP2-15776]

Western Blot: gp130/CD130 Antibody [NBP2-15776] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with CD130 antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Immunocytochemistry/ Immunofluorescence: gp130/CD130 Antibody [NBP2-15776]

Immunocytochemistry/ Immunofluorescence: gp130/CD130 Antibody [NBP2-15776]

Immunocytochemistry/Immunofluorescence: gp130/CD130 Antibody [NBP2-15776] - HeLa cells were fixed in ice-cold MeOH for 5 min. Green: IL6ST protein stained by CD130 antibody diluted at 1:500. Blue: Hoechst 33342 staining.
Immunohistochemistry-Paraffin: gp130/CD130 Antibody [NBP2-15776]

Immunohistochemistry-Paraffin: gp130/CD130 Antibody [NBP2-15776]

Immunohistochemistry-Paraffin: gp130/CD130 Antibody [NBP2-15776] - Human breast carcinoma. CD130 stained by CD130 antibody diluted at 1:7500.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
View 1 more images

Applications for gp130/CD130 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: gp130

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Long Name

Glycoprotein 130

Alternate Names

CD130, IL6ST

Gene Symbol

IL6ST

UniProt

P40189

Additional gp130 Products

Product Documents for gp130/CD130 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for gp130/CD130 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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