GRK1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55226

Novus Biologicals, part of Bio-Techne
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NBP2-55226
NBP2-55226-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human, Monkey

Cited:

Primate - Macaca mulatta (Rhesus Macaque)

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GRK1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSA

Reactivity Notes

Use in Monkey reported in scientific literature (PMID:35024589) Mouse 85%, Rat 82%.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GRK1 Antibody

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human colon, eye, retina, liver and lymph node using Anti-GRK1 antibody NBP2-55226 (A) shows similar protein distribution across tissues to independent antibody NBP2-55732 (B).
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human eye, retina.
Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226]

Immunohistochemistry-Paraffin: GRK1 Antibody [NBP2-55226] - Staining of human lymph node.
View 2 more images

Applications for GRK1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Frozen

Reported in scientific literature (PMID:35024589)

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GRK1

The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.

Long Name

G protein-coupled Receptor Kinase 1

Alternate Names

GPRK1, RHOK

Gene Symbol

GRK1

Additional GRK1 Products

Product Documents for GRK1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for GRK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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