GRK3 Antibody (SR2232)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21869

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21869-100ul
NBP3-21869-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2232

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GRK3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human GRK3 (Uniprot #: P35626)

Specificity

Detects endogenous levels of total GRK3

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GRK3 Antibody (SR2232)

Western Blot: GRK3 Antibody (SR2232) [NBP3-21869] -

Western Blot: GRK3 Antibody (SR2232) [NBP3-21869] - Western blot analysis using NBP3-21869 in Ramos cell lysate.

Applications for GRK3 Antibody (SR2232)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GRK3

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second essenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7.

Long Name

G protein-coupled Receptor Kinase 3

Alternate Names

ADRBK2, BARK2, Beta-ARK-2

Gene Symbol

GRK3

Additional GRK3 Products

Product Documents for GRK3 Antibody (SR2232)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GRK3 Antibody (SR2232)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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