HEXA encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq]

Alternate Names

HEXA, TSD

Gene Symbol

HEXA

UniProt

NP_000511.1 (Human)

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Product Specific Notices for Hexosaminidase A/HEXA Antibody (20F1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Hexosaminidase A/HEXA Antibody (20F1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42629

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Western Blot: Hexosaminidase A/HEXA Antibody (20F1)BSA Free [NBP2-42629]

Western Blot: Hexosaminidase A/HEXA Antibody (20F1)BSA Free [NBP2-42629]

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Background: Hexosaminidase A/HEXA