Hexosaminidase A/HEXA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21239

Novus Biologicals, part of Bio-Techne
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NBP3-21239-100ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Hexosaminidase A/HEXA Antibodies »

Product Summary for Hexosaminidase A/HEXA Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Hexosaminidase A/HEXA Antibody

Immunocytochemistry/Immunofluorescence: Hexosaminidase A/HEXA Antibody [NBP3-21239] -

Immunocytochemistry/Immunofluorescence: Hexosaminidase A/HEXA Antibody [NBP3-21239] -

Staining of human cell line SK-MEL-30 shows localization to vesicles.

Applications for Hexosaminidase A/HEXA Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Hexosaminidase A/HEXA

HEXA encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq]

Alternate Names

HEXA, TSD

Gene Symbol

HEXA

Additional Hexosaminidase A/HEXA Products

Product Documents for Hexosaminidase A/HEXA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Hexosaminidase A/HEXA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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