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Human ADAMTS13 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB42451

R&D Systems, part of Bio-Techne
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MAB42451-100
MAB42451-SP

Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 442315

Product Specifications

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS13

Gln34-Trp688
Accession # Q76LX8

Specificity

Detects human ADAMTS13 in ELISA

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human ADAMTS13 Antibody

Application
Recommended Usage

ELISA

This antibody functions as an ELISA detection antibody when paired with Sheep anti-ADAMTS13 polyclonal antibody (Catalog # AF4245).This product is intended for assay development on various assay platforms requiring antibody pairs.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ADAMTS13

ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) is a secreted multi-domain zinc protease primarily produced by the liver. In the circulation, it is responsible for cleaving von Willebrand factor (vWF) between Tyr842 and Met843. Defects in ADAMTS13 activity result in the generation of ultra large vWF, leading to thrombotic thrombocytopenic purpura (TTP). The amino acid sequence of human ADAMTS13 in the region of aa 34 to 688 is 76% identical to that of mouse/rat.

Long Name

A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 13

Alternate Names

TTP, vWF-CP

Entrez Gene IDs

11093 (Human); 279028 (Mouse); 362091 (Rat)

Gene Symbol

ADAMTS13

UniProt

Additional ADAMTS13 Products

Product Documents for Human ADAMTS13 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human ADAMTS13 Antibody

For research use only

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