Human ADAMTS13 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF4245
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS13
Gln34-Trp688
Accession # Q76LX8
Gln34-Trp688
Accession # Q76LX8
Specificity
Detects human ADAMTS13 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) ADAMTS1, rhADAMTSL-1.2, rhADAMTS4, and rhADAMTS5 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human ADAMTS13 Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human ADAMTS13 (Catalog # 4245-AD)
Sample: Recombinant Human ADAMTS13 (Catalog # 4245-AD)
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ADAMTS13
ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) is a secreted multi-domain zinc protease primarily produced by the liver. In the circulation, it is responsible for cleaving von Willebrand factor (vWF) between Tyr842 and Met843. Defects in ADAMTS13 activity result in the generation of ultra large vWF, leading to thrombotic thrombocytopenic purpura (TTP). The amino acid sequence of human ADAMTS13 in the region of aa 34 to 688 is 76% identical to that of mouse/rat.
Long Name
A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 13
Alternate Names
TTP, vWF-CP
Gene Symbol
ADAMTS13
UniProt
Additional ADAMTS13 Products
Product Documents for Human ADAMTS13 Biotinylated Antibody
Product Specific Notices for Human ADAMTS13 Biotinylated Antibody
For research use only
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