Human ALK/CD246 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB4210
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # 383625
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ALK/CD246
Val19-Ser1038
Accession # Q9UM73
Val19-Ser1038
Accession # Q9UM73
Specificity
Detects human ALK/CD246 in direct ELISAs and Western blots.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human ALK/CD246 Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human ALK/CD246
Sample: Recombinant Human ALK/CD246
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ALK/CD246
Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDLR class A domain, two MAM domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Long Name
Anaplastic Lymphoma Kinase
Alternate Names
CD246, Ki-1, Tcrz
Gene Symbol
ALK
UniProt
Additional ALK/CD246 Products
Product Documents for Human ALK/CD246 Antibody
Product Specific Notices for Human ALK/CD246 Antibody
This product or use of this product is covered by US Patent 6,696,548 and other international patents. This product is for research use only. Use of this product for diagnostic or therapeutic purposes or for drug discovery or development is prohibited.
For research use only
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