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Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB10547

Recombinant Monoclonal Antibody For Research Use Only
R&D Systems, part of Bio-Techne
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MAB10547-100
MAB10547-SP

Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # Hu129

Product Specifications

Immunogen

Human Il-17 Receptor

Specificity

Detects human IL-17RA/IL-17R based on Brodalumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Brodalumab. This product is for research use only.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Scientific Data Images for Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

Detection of IL-17RA/IL-17R antibody in K562 human cell line antibody by Flow Cytometry.

Detection of IL-17RA/IL-17R in K562 human cell line by Flow Cytometry.

K562 human myelogenous leukemia cell line was stained with Human Anti-Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Monoclonal Antibody (Catalog # MAB10547, filled histogram) or Human IgG control antibody (open histogram) followed by anti-human IgG APC-conjugated Secondary Antibody (F0135). Staining was performed using our Staining Membrane-associated Proteins protocol.

Applications for Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

0.25 µg/106 cells
Sample: K562 human myelogenous leukemia cell line
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17RA/IL-17R

Brodalumab is a human monoclonal antibody designed for the treatment of inflammatory diseases. Brodalumab binds to the interleukin-17 receptor and so prevents interleukin 17 (IL-17) from activating the receptor.

Long Name

Interleukin 17 Receptor

Alternate Names

CD217, Cdw217, IL-17 R, IL-17 RA, IL17RA

Entrez Gene IDs

23765 (Human); 16172 (Mouse); 312679 (Rat); 486759 (Canine); 101925679 (Cynomolgus Monkey)

Gene Symbol

IL17RA

Additional IL-17RA/IL-17R Products

Product Documents for Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human IL-17RA/IL-17R (Research Grade Brodalumab Biosimilar) Antibody

For research use only

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