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Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB8919R

Recombinant Monoclonal Antibody.
R&D Systems, part of Bio-Techne
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FAB8919R-025
FAB8919R-100

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Alexa Fluor 647 (Excitation = 650 nm, Emission = 668 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 1136B

Product Specifications

Immunogen

Human embryonic kidney cell line HEK293-derived recombinant human KIR3DL3/CD158z
Met1-Leu322
Accession # Q8N743

Specificity

Detects human KIR3DL3/CD158z in direct ELISAs.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody

Detection of KIR3DL3/CD158z antibody in BaF3 Mouse Cell Line Transfected with KIR3DL3/CD158z antibody by Flow Cytometry.

Detection of KIR3DL3/CD158z in BaF3 Mouse Cell Line Transfected with KIR3DL3/CD158z by Flow Cytometry.

BaF3 mouse pro-B cell line transfected with KIR3DL3/CD158z was stained with Rabbit Anti-Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # FAB8919R, filled histogram) or control antibody Rabbit Anti-Human KIR2DS5/CD185g Alexa Fluor® 647-conjugated Antibody (Catalog # FAB8920R, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

5 µL/106 cells
Sample:   BaF3 mouse pro-B cell line transfected with KIR3DL3/CD158z

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: KIR3DL3/CD158z

KIR3DL3 is a member of the Killer-Immunoglobulin-like Receptor (KIR) family, a functionally diverse family of transmembrane receptors expressed primarily on NK cells. KIR3DL3 is a “framework” KIR gene, and is present in all individuals, in contrast to non-framework KIRs, whose gene content varies by KIR haplotype. KIR3DL3 is expressed at low or undetectable levels in peripheral blood NK cells, but expression can be induced in NK cell lines by demethylation agents, indicating that promoter DNA methylation inhibits KIR3DL3 transcription. Despite the lack of evidence for surface protein expression, KIR3DL3 mRNA expression has been detected in both decidual and peripheral blood NK cells in normal, disease-free conditions. Over amino acids (aa) 1-322, human KIR3DL3 shares 47% aa sequence identity with mouse KIR3DL1.

Long Name

Killer Cell Immunoglobulin-like Receptor, Three Domain Long Cytoplasmic Tail, 3

Alternate Names

CD158z, KIR3DL7, KIR44, KIRC1

Entrez Gene IDs

115653 (Human)

Gene Symbol

KIR3DL3

UniProt

Additional KIR3DL3/CD158z Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human KIR3DL3/CD158z Alexa Fluor® 647-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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