Human Neurophysin II Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB009

R&D Systems, part of Bio-Techne
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MAB009-100
MAB009-SP
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 62865

View all Neurophysin II Antibodies »

Product Specifications

Immunogen

Synthetic peptide containing human Neurophysin II
Accession # P01186

Specificity

Detects human Neurophysin II in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human Neurophysin II Antibody

Neurophysin II antibody in Human Brain Hippocampus Tissue by Immunohistochemistry (IHC-P).

Neurophysin II in Human Brain Hippocampus Tissue.

Neurophysin II was detected in immersion fixed paraffin-embedded sections of human brain hippocampus tissue using Mouse Anti-Human Neurophysin II Monoclonal Antibody (Catalog # MAB009) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neurons. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human Neurophysin II Antibody

Application
Recommended Usage

Immunohistochemistry

5-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain hippocampus tissue

Reviewed Applications

Read 1 review rated 5 using MAB009 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neurophysin II

Arginine vasopressin (AVP)/Neurophysin 2 is a hormone synthesized in neurons in the hypothalamus that specifically binds vasopressin.  Vasopressin has a direct antidiuretic action on the kidney and causes vasoconstriction of the peripheral vessels.  Vasopressin regulates the tonicity of body fluid by causing the kidneys to reabsorb solute-free water and returning it to the circulation from the tubules of the nephron.  AVP released in high concentrations may also raise blood pressure by inducing vasoconstriction.  The stimulus for secretion of vasopressin is increased osmolality of the plasma which is monitored by the hypothalamus.  Vasopressin is often used to manage anti-diuretic hormone deficiency.

Alternate Names

ARVP, AVP, AVP-NPII, AVRP, NP2

Entrez Gene IDs

551 (Human); 24221 (Rat)

Gene Symbol

AVP

UniProt

P01186

Additional Neurophysin II Products

Product Documents for Human Neurophysin II Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Neurophysin II Antibody

For research use only

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