Human PILR-beta PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB4189P
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human PILR-beta isoform 1
Gln20-Ala189
Accession # Q9UKJ0
Gln20-Ala189
Accession # Q9UKJ0
Specificity
Detects recombinant human PILR-beta in direct ELISAs and Western blots. In Western blots, approximately 10% cross reactivity with recombinant human PILR-alpha is observed and less than 5% cross-reactivity with recombinant mouse (rm) PILR-beta, rmPILR-alpha, and rmPILR-L is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Scientific Data Images for Human PILR-beta PE-conjugated Antibody
Detection of PILR‑ beta in Human Peripheral Blood Granulocytes by Flow Cytometry.
Human peripheral blood granulocytes were stained with Sheep Anti-Human PILR-beta PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB4189P, filled histogram) or isotype control antibody (Catalog # IC016P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human PILR-beta PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
5 µL/106 cells
Sample: Human peripheral blood granulocytes
Sample: Human peripheral blood granulocytes
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Background: PILR-beta
Paired immunoglobulin-like, type 2 receptor beta (PILR-beta) is a type I transmembrane (TM) glycoprotein belonging to the Ig superfamily. It is the activating counterpart to the ITIM-bearing PILR-alpha inhibitory receptor. PILR-beta is expressed in a wide variety of hematopoietic cells, including NK cells, macrophages, dendritic cells and neutrophils. Mature human PILR-beta is a 208 amino acid (aa) protein with one V-type Ig-like extracellular domain, a truncated cytoplasmic tail, and a positively-charged residues in its TM domain that interacts with ITAM‑bearing adaptor molecules. Over aa 20-189, in their ECD, human PILR-beta and PILR-alpha share 82% aa sequence identity. The aa sequence of mouse PILR-beta ECD is only 43% identical to that of human PILR-beta ECD.
Long Name
Paired-Ig-likeType 2 Receptor beta
Alternate Names
FDFACT1, FDFACT2, PILRB, PILRbeta
Gene Symbol
PILRB
UniProt
Additional PILR-beta Products
Product Documents for Human PILR-beta PE-conjugated Antibody
Product Specific Notices for Human PILR-beta PE-conjugated Antibody
For research use only
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