Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF166

R&D Systems, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

Immunocytochemistry

Label

Biotin

Antibody Source

Polyclonal Goat IgG

View all Presenilin-1 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Presenilin-1
aa 298-407

Specificity

Detects human Presenilin‑1 C-Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human (rh) Presenilin‑1 N-Terminal Fragment  (aa 1‑80) and rhPresenilin‑2 C-Terminal Fragment  (aa 322‑388) is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

Application
Recommended Usage

Immunohistochemistry

5-15 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain (hippocampus)

Western Blot

0.1 µg/mL
Sample: Recombinant Human Presenilin-1 C-Terminal Fragment

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

Alternate Names

Presenilin1, PSEN1, S182

Entrez Gene IDs

5663 (Human)

Gene Symbol

PSEN1

Additional Presenilin-1 Products

Product Documents for Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

For research use only

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