Human Presenilin-2 C-Terminal Fragment Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB1218

R&D Systems, part of Bio-Techne
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MAB1218
MAB1218-SP
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 149903

View all Presenilin-2 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Presenilin‑2 C-Terminal Fragment
Glu322-Thr388
Accession # P49810

Specificity

Detects human Presenilin‑2 C-Terminal Fragment in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) Presenilin‑1 C-Terminal Fragment, rhPresenilin‑1 N-Terminal Fragment, or rhPresenilin‑2 N-Terminal Fragment is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Presenilin-2 C-Terminal Fragment Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Presenilin-2 C-Terminal Fragment
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-2

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

Alternate Names

Presenilin2, PSEN2

Entrez Gene IDs

5664 (Human)

Gene Symbol

PSEN2

UniProt

P49810

Additional Presenilin-2 Products

Product Documents for Human Presenilin-2 C-Terminal Fragment Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Presenilin-2 C-Terminal Fragment Antibody

For research use only

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