Presenilin-2 Products
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
60 results for "Presenilin-2" in Products
60 results for "Presenilin-2" in Products
Presenilin-2 Products
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
DAPT synthesized to Ancillary Material Grade
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
γ-secretase inhibitor; inhibits Notch pathway
| Alternate Names: | Dibenzazepine,YO-01027 |
| Chemical Name: | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 21 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Presenilin-2 Antibody (APS 21) [NB100-74512]](https://resources.bio-techne.com/images/products/Presenilin-2-Antibody-APS-21-Western-Blot-NB100-74512-img0009.jpg "Western Blot: Presenilin-2 Antibody (APS 21) [NB100-74512]")
Potent γ-secretase inhibitor
| Chemical Name: | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: Presenilin-2 Antibody (APS 26) [NB100-74513]](https://resources.bio-techne.com/images/products/Presenilin-2-Antibody-APS-26-Western-Blot-NB100-74513-img0009.jpg "Western Blot: Presenilin-2 Antibody (APS 26) [NB100-74513]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #149903 |
| Applications: | WB |
Potent γ-secretase inhibitor
| Chemical Name: | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name: | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity: | ≥99% (HPLC) |
Highly potent γ-secretase inhibitor; orally bioavailable
| Chemical Name: | (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide |
| Purity: | ≥98% |
γ-secretase pseudo-inhibitor
| Chemical Name: | (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide |
| Purity: | ≥98% (HPLC) |
| Applications: | WB |
![Western Blot: Presenilin-2 Overexpression Lysate [NBP2-10350]](https://resources.bio-techne.com/images/products/Presenilin-2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-10350-img0001.jpg "Western Blot: Presenilin-2 Overexpression Lysate [NBP2-10350]")
| Applications: | WB, ELISA, MA, AP, PAGE |
![SDS-PAGE: Recombinant Human Presenilin-2 GST (N-Term) Protein [H00005664-Q01]](https://resources.bio-techne.com/images/products/qc_test-H00005664-Q01-1.jpg "SDS-PAGE: Recombinant Human Presenilin-2 GST (N-Term) Protein [H00005664-Q01]")
| Applications: | ELISA |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
| Reactivity: | Human, Mouse, Primate, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #APS 21 |
| Applications: | IHC, WB, ICC/IF, ELISA |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #APS 26 |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
| Reactivity: | Human, Mouse, Primate, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #APS 21 |
| Applications: | IHC, WB, ICC/IF, ELISA |