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Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3485

R&D Systems, part of Bio-Techne
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AF3485
AF3485-SP

Key Product Details

Species Reactivity

Validated:

Human, Primate

Cited:

Human, Rat

Applications

Validated:

ELISA Capture (Matched Antibody Pair), Simple Western, Western Blot

Cited:

ELISA Capture, ELISA Development, ELISA Development (Capture), ELISA Development (Detection), Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Angiopoietin-like 4/ANGPLT4
Leu165-Ser406
Accession # Q9BY76

Specificity

Detects human ANGPTL4 in ELISAs and Western blots. In sandwich immunoassays, less than 0.2% cross-reactivity with recombinant human (rh) ANGPTL3, rhAngiopoietin-1, -2, -3, and -4 is observed. In Western blots, approximately 1% cross-reactivity with rhANGPLT4 N-terminal Fragment is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody

Detection of Human/Primate Angiopoietin-like Protein 4/ANGPTL4 by Simple WesternTM.

Simple Western lane view shows lysates of Human Diabetic Adipose, loaded at 0.2 mg/mL. A specific band was detected for Angiopoietin-like Protein 4/ANGPTL4 at approximately 59 kDa (as indicated) using 50 µg/mL of Goat Anti-Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3485). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Applications for Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody

Application
Recommended Usage

Simple Western

50 µg/mL
Sample: Human Diabetic Adipose

Western Blot

0.1 µg/mL
Sample: Recombinant Human Angiopoietin-like 4/ANGPTL4 (Catalog # 4487-AN)

Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Sandwich Immunoassay

ELISA Capture (Matched Antibody Pair)
Recommended Concentration: 0.2-0.8 µg/mL
Use in combination with these reagents:
  • Detection Reagent: Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Biotinylated Antibody (Catalog # BAF3485)
  • Standard: Recombinant Human Angiopoietin-like 4 Protein, CF (Catalog # 4487-AN)
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Angiopoietin-like Protein 4/ANGPTL4

ANGPTL4, also known as PPAR gamma angiopoietin-related protein (PGAR), hepatic fibrinogen/angiopoietin-related protein (HFARP) and fasting-induced adipose factor (FIAF), is a secreted protein that shares structural homology with angiopoietins. It contains an N-terminal coiled-coil region that mediates covalent homo-oligomerization and a C-terminal fibrinogen-like domain. ANGPTL4 undergoes proteolytic processing and releases the C-terminal domain, which circulates as a monomer. At least 2 additional splice isoforms exist. ANGPTL4 is most highly expressed in adipose tissues. Its expression is up-regulated in endothelial cells and cardiomyocytes during hypoxia. ANGPTL4 is involved in the regulation of lipid and glucose metabolism. It has also been associated with angiogenesis. The amino acid sequence of human ANGPTL4 is 81%, 76% and 81% identical to that of porcine, mouse and canine ANGPTL4, respectively.

Alternate Names

Angiopoietin like Protein 4, ANGPTL4, FIAF, HFARP, PGAR

Entrez Gene IDs

51129 (Human); 57875 (Mouse); 362850 (Rat)

Gene Symbol

ANGPTL4

UniProt

Additional Angiopoietin-like Protein 4/ANGPTL4 Products

Product Documents for Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody

For research use only

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