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Human Prohibitin Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3470

R&D Systems, part of Bio-Techne
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AF3470
AF3470-SP

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

E. coli-derived recombinant human Prohibitin
Ala2-Gln272
Accession # P35232

Specificity

Detects human Prohibitin in direct ELISAs and Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human Prohibitin Antibody

Prohibitin antibody in MCF-7 Human Cell Line by Immunocytochemistry (ICC).

Prohibitin in MCF‑7 Human Cell Line.

Prohibitin was detected in immersion fixed MCF-7 human breast cancer cell line using Goat Anti-Human Prohibitin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3470) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Applications for Human Prohibitin Antibody

Application
Recommended Usage

Immunocytochemistry

5-15 µg/mL
Sample: Immersion fixed MCF-7 human breast cancer cell line

Western Blot

0.1 µg/mL
Sample: Recombinant Human Prohibitin
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Prohibitin

Prohibitin is an approximately 30 kDa protein that belongs to the prohibitin family. It contains a characteristic prohibitin domain and has been shown to have multiple functions. It can be localized to the mitochondria, nucleus, plasma membrane, and is also present in circulation. Post translational modifications of Prohibitin, including phosphorylation and ubiquitination, also occurs. Human Prohibitin shares 99% amino acid sequence identity with the mouse or rat protein.

Alternate Names

PHB

Entrez Gene IDs

5245 (Human); 18673 (Mouse); 25344 (Rat)

Gene Symbol

PHB

UniProt

Additional Prohibitin Products

Product Documents for Human Prohibitin Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Prohibitin Antibody

For research use only

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