Human TM4SF1/L6 PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB8164P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 877621
Product Specifications
Immunogen
NS0 mouse myeloma cell line transfected with human TM4SF1/L6
Met1-Cys202
Accession # P30408
Met1-Cys202
Accession # P30408
Specificity
Detects human TM4SF1/L6 in ELISA. Stains human TM4SF1/L6 transfected cells but not irrelevant transfectants.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Scientific Data Images for Human TM4SF1/L6 PE-conjugated Antibody
Detection of TM4SF1/L6 in A549 Human Cell Line by Flow Cytometry.
A549 human lung carcinoma cell line was stained with Mouse Anti-Human TM4SF1/L6 PE-conjugated Monoclonal Antibody (Catalog # FAB8164P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of TM4SF1/L6 in HEK293 Human Cell Line Transfected with Human TM4SF1/L6 and eGFP by Flow Cytometry.
HEK293 human embryonic kidney cell line transfected with human TM4SF1/L6 and eGFP was stained with either (A) Mouse Anti-Human TM4SF1/L6 PE-conjugated Monoclonal Antibody (Catalog # FAB8164P) or (B) Mouse IgG1Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.Applications for Human TM4SF1/L6 PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: A549 human lung carcinoma cell line and HEK293 human embryonic kidney cell line transfected with human TM4SF1/L6 and eGFP
Sample: A549 human lung carcinoma cell line and HEK293 human embryonic kidney cell line transfected with human TM4SF1/L6 and eGFP
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TM4SF1/L6
|
TM4SF1 (Transmembrane 4 L6 family Member 1; also L6 and M3s1) is a 23-28
kDa member of the L6 tetraspanin family of molecules. It is expressed
by fibroblasts, endothelial cells and a variety of tumor cells. TM4SF1
is embedded in both the plasma membrane and the membrane of late
endocytic organelles. Here, it appears to be ubiquitinated, and to
regulate endocytosis, an action that impacts effective cell migration.
TM4SF1 is reported to interact with alpha5 and beta1 integrins, and this may
impact cell motility. It also suppresses the expression of CD63 and
CD82, two molecules that impede cell mobility. Human TM4SF1 is a 202
amino acid (aa) 4‑transmembrane (TM) glycoprotein. It contains a short
N-terminal cytoplasmic region (aa 1-9), followed by four TM regions and
another C-terminal cytoplasmic region (aa 183-202). Human TM4SF1 shares
78% and 80% aa sequence identity with mouse and rat TM4SF1,
respectively. |
Long Name
Transmembrane 4 L Six Family Member 1
Alternate Names
L6, M3s1, TAAL6
Gene Symbol
TM4SF1
UniProt
Additional TM4SF1/L6 Products
Product Documents for Human TM4SF1/L6 PE-conjugated Antibody
Product Specific Notices for Human TM4SF1/L6 PE-conjugated Antibody
For research use only
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