ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Long Name

Intercellular Adhesion Molecule 1

Alternate Names

CD54, ICAM1

Gene Symbol

ICAM1

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Product Documents for ICAM-1/CD54 Antibody (ICAM1/8677R) [Janelia Fluor® 646]

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Product Specific Notices for ICAM-1/CD54 Antibody (ICAM1/8677R) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICAM-1/CD54 Antibody (ICAM1/8677R) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24243JF646

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Applications for ICAM-1/CD54 Antibody (ICAM1/8677R) [Janelia Fluor® 646]

Immunohistochemistry-Paraffin

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Background: ICAM-1/CD54