IGF-I R/IGF1R Antibody (1H7)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-66537

Novus Biologicals, part of Bio-Techne
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NB100-66537
NB100-66537-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1H7

Concentration

1.0 mg/ml

View all IGF-I R/IGF1R Antibodies »

Product Specifications

Immunogen

Purified human placental IGF-I receptor

Specificity

NB100-66537 recognizes human CD221

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IGF-I R/IGF1R Antibody (1H7)

Flow Cytometry: IGF-I R/IGF1R Antibody (1H7) - BSA Free [NB100-66537]

Flow Cytometry: IGF-I R/IGF1R Antibody (1H7) - BSA Free [NB100-66537]

Flow Cytometry: IGF-I R Antibody (1H7) [NB100-66537] - Staining of human peripheral blood granulocytes with mouse anti human CD221 (NB100-66537).

Applications for IGF-I R/IGF1R Antibody (1H7)

Application
Recommended Usage

Flow Cytometry

1:10

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:40

Western Blot

1:100-1:2000
Application Notes
For Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. This product requires protein digestion pretreatment of paraffin sections e.g. trypsin or pronase.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGF-I R/IGF1R

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Entrez Gene IDs

3480 (Human)

Gene Symbol

IGF1R

UniProt

P08069

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R Antibody (1H7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGF-I R/IGF1R Antibody (1H7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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