This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Long Name

Interleukin 12 p35

Alternate Names

IL-12A, IL35p35

Gene Symbol

IL12A

Additional IL-12/IL-35 p35 Products

Product Documents for IL-12/IL-35 p35 Antibody (B-T21) [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for IL-12/IL-35 p35 Antibody (B-T21) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

IL-12/IL-35 p35 Antibody (B-T21) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14604JF646

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all IL-12/IL-35 p35 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for IL-12/IL-35 p35 Antibody (B-T21) [Janelia Fluor® 646]

ELISA

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: IL-12/IL-35 p35