Inhibin alpha Antibody (R1) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08781

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # R1

Format

Azide and BSA Free

Concentration

1 mg/ml

View all Inhibin A Antibodies »

Product Summary for Inhibin alpha Antibody (R1) - Azide and BSA Free

Immunogen

A synthetic peptide corresponding to Human Inhibin alpha aa 233-264. Note that this peptide corresponds to the N-terminus of the mature region of the human inhibin alpha subunit. (Uniprot: P05111 )

Localization

Cytoplasmic (secreted) and Nuclear

Marker

Gonadal Cell Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Theoretical MW

47 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-07459).

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C.

Scientific Data Images for Inhibin alpha Antibody (R1) - Azide and BSA Free

Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781]

Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781]

Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781] - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Inhibin alpha Mouse Monoclonal Antibody (R1).
Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781]

Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781]

Immunohistochemistry-Paraffin: Inhibin alpha Antibody (R1) - Azide and BSA Free [NBP3-08781] - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Inhibin alpha Mouse Monoclonal Antibody (R1).

Applications for Inhibin alpha Antibody (R1) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry Formalin-fixed: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

1 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Inhibin A

INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Alternate Names

INHA, Inhibin A

Gene Symbol

INHA

Additional Inhibin A Products

Product Documents for Inhibin alpha Antibody (R1) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Inhibin alpha Antibody (R1) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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