Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49602F

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-49602AF350

Alexa Fluor 405

NBP1-49602AF405

Alexa Fluor 488

NBP1-49602AF488

Alexa Fluor 532

NBP1-49602AF532

Alexa Fluor 594

NBP1-49602AF594

Alexa Fluor 647

NBP1-49602AF647

Alexa Fluor 700

NBP1-49602AF700

Alexa Fluor 750

NBP1-49602AF750

Allophycocyanin

NBP1-49602APC

Biotin

NBP1-49602B

CoraFluor 1

NBP1-49602CL1

DyLight 350

NBP1-49602UV

DyLight 405

NBP1-49602V

DyLight 488

NBP1-49602G

DyLight 550

NBP1-49602R

DyLight 594

NBP1-49602DL594

DyLight 650

NBP1-49602C

DyLight 680

NBP1-49602FR

DyLight 755

NBP1-49602IR

HRP

NBP1-49602H

Janelia Fluor 525

NBP1-49602JF525

Janelia Fluor 549

NBP1-49602JF549

Janelia Fluor 585

NBP1-49602JF585

Janelia Fluor 635

NBP1-49602JF635

Janelia Fluor 646

NBP1-49602JF646

Janelia Fluor 669

NBP1-49602JF669

mFluor Violet 450 SE

NBP1-49602MFV450

mFluor Violet 500 SE

NBP1-49602MFV500

mFluor Violet 610 SE

NBP1-49602MFV610

PE

NBP1-49602PE

PerCP

NBP1-49602PCP

Forumulation

Catalog #

BSA Free

NBP1-49602

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Lysine (K)-specific Demethylase 4A/KDM4A Antibodies »

Product Summary for Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody [FITC]

Immunogen

A genomic peptide made to an internal region of the human JMJD2A protein (within residues 320-460). [Swiss-Prot O75164]

Localization

Nucleus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody [FITC]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Lysine (K)-specific Demethylase 4A/KDM4A

Jumonji lysine demethylases (JMJDs) are oxygenases catalyzing demethylation of mono-, di-, or trimethylated lysines, and its members (JMJD2A, JMJD2B, JMJD2C, and JMJD2D) are Fe(II)- and alpha-ketoglutarate-dependent enzymes harboring a JmjC catalytic domain. JMJD2A (JHDM3 or KDM4A) catalyzes the demethylation of di- and trimethylated H3K9 and H3K36 and participate in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of HDACs and NCOR1, respectively. JMJD2A as well as JMJD2C have been suggested to act as co-activators of AR-dependent gene transcription. JMJD2A is widely expressed in human tissues and cell lines with high expression in human T-cell lymphotropic virus 1-infected cell lines, HT1376 bladder carcinoma cell line, U2OS osteosarcoma cell line and prostate cancer cell lines. JMJD2A is overexpressed in mouse and human lung cancers has been proposed as an oncogene that represents a target for Ras-expressing tumors. Silencing of JMJD2A gene has been shown to result in cell cycle change and proliferation inhibition, and suppression of tumor cell migration/ invasion.

Alternate Names

JHDM3A, JMJD2, JMJD2A, KDM4A, Lysine (K)specific Demethylase 4A

Gene Symbol

KDM4A

Additional Lysine (K)-specific Demethylase 4A/KDM4A Products

Product Documents for Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody [FITC]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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