MAVS Antibody (58N3E1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-22378

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 58N3E1

Concentration

0.5 mg/ml

View all MAVS Antibodies »

Product Summary for MAVS Antibody (58N3E1)

Immunogen

Within the range of amino acids 93-298 of human MAVS (isoform 1) were used as the immunogen for this antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for MAVS Antibody (58N3E1)

Western Blot: MAVS Antibody (58N3E1) [NBP2-22378]

Western Blot: MAVS Antibody (58N3E1) [NBP2-22378]

Western Blot: MAVS Antibody (58N3E1) [NBP2-22378] - Western blot analysis of HEK293 lysate (35 ug per lane, RIPA buffer) using MAVS antibody (NBP2-22378) at 0.3ug/ml. Band observed at ~65kDa. (Expected MW of 56.5kDa according to NP_065797.2).
Western Blot: MAVS Antibody (58N3E1) [NBP2-22378]

Western Blot: MAVS Antibody (58N3E1) [NBP2-22378]

Western Blot: MAVS Antibody (58N3E1) [NBP2-22378] - Analysis of A) partial recombinant protein and B) human HeLa lysate using IPS-1 antibody at 0.1 ug/ml and 2 ug/ml, respectively. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for MAVS Antibody (58N3E1)

Application
Recommended Usage

Western Blot

0.1-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

UniProt

AAH44952.1 (Human)

Additional MAVS Products

Product Documents for MAVS Antibody (58N3E1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAVS Antibody (58N3E1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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