Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # MERTK/3023

Concentration

0.2 mg/ml

View all Mer Antibodies »

Product Specifications

Immunogen

Recombinant human Mer protein fragment (around aa 55-148) (exact sequence is proprietary) (Uniprot: Q12866)

Reactivity Notes

Others not known.

Localization

Cell surface

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-14234)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C.

Scientific Data Images for Mer Antibody (MERTK/3023)

Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838]

Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838]

Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838] - Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Mer antibody (MERTK/3023).
Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838]

Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838]

Immunohistochemistry-Paraffin: Mer Antibody (MERTK/3023) [NBP3-13838] - Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Mer antibody (MERTK/3023).
Protein Array: Mer Antibody (MERTK/3023) [NBP3-13838]

Protein Array: Mer Antibody (MERTK/3023) [NBP3-13838]

Protein Array: Mer Antibody (MERTK/3023) [NBP3-13838] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Mer Antibody (MERTK/3023).

Applications for Mer Antibody (MERTK/3023)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Mer

MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice; with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Long Name

Receptor Tyrosine Protein Kinase Mer

Alternate Names

c-Eyk, C-mer, MerTK

Gene Symbol

MERTK

UniProt

Q12866

Additional Mer Products

Product Documents for Mer Antibody (MERTK/3023)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Mer Antibody (MERTK/3023)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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