Mouse Noggin Biotinylated Antibody

Noggin is a 232 amino acid (aa), ~31 kDa homodimer-forming glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Noggin is expressed in defined areas during development and in the adult central nervous system and peripheral tissues such as lung, skeletal muscle, and skin. It is important for neural tube, somite and cardiomyocyte growth and patterning, and for limiting chondrocyte growth. Noggin is secreted but probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Mature human, mouse, and rat Noggin share 99% aa sequence identity.