Nectin-2/CD112 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-91211

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Nectin-2/CD112 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Nectin-2/CD112 Antibody

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211] - Staining in human placenta and cerebral cortex tissues . Corresponding NECTIN2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211]

Immunohistochemistry-Paraffin: Nectin-2/CD112 Antibody [NBP1-91211] - Staining of human liver shows moderate membranous positivity in hepatocytes.
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Applications for Nectin-2/CD112 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nectin-2/CD112

Nectin 2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Long Name

Poliovirus Receptor Related 2

Alternate Names

CD112, HVEB, MPH, Nectin2, PRR2, PVRL2

Gene Symbol

NECTIN2

Additional Nectin-2/CD112 Products

Product Documents for Nectin-2/CD112 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Nectin-2/CD112 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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