Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all OTUD5 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human OTUD5. The immunogen is located within amino acids 400 - 450 of OTUD5. Amino Acid Squence: VRGPSQPKASAT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for OTUD5 Antibody - BSA Free

Western Blot: OTUD5 AntibodyBSA Free [NBP1-76943]

Western Blot: OTUD5 AntibodyBSA Free [NBP1-76943]

Western Blot: OTUD5 Antibody [NBP1-76943] - Human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 ug/mL.
OTUD5 Antibody - BSA Free

Immunohistochemistry: OTUD5 Antibody - BSA Free [NBP1-76943] -

Immunohistochemistry: OTUD5 Antibody - BSA Free [NBP1-76943] - Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 ug/mL.
OTUD5 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: OTUD5 Antibody - BSA Free [NBP1-76943] -

Immunocytochemistry/ Immunofluorescence: OTUD5 Antibody - BSA Free [NBP1-76943] - Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 ug/mL.

Applications for OTUD5 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: OTUD5

OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.

Alternate Names

Deubiquitinating enzyme A, DKFZp761A052, DUBAdeubiquinating enzyme A, EC 3.4.19.12, MGC104871, OTU domain containing 5, OTU domain-containing protein 5

Gene Symbol

OTUD5

UniProt

EAW50723 (Human)

Additional OTUD5 Products

Product Documents for OTUD5 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for OTUD5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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