PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-71770G

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Label

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # N2-11

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PAR1 Antibodies »

Product Specifications

Immunogen

The oligopeptide CNATLDPRSFLL from human Thrombin Receptor. [Swiss-Prot# P25116]

Localization

Cell membrane; Multi-pass membrane protein.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PAR1

Thrombin Receptor, also known as Protease activated receptor 1 (PAR1), is a G-protein-coupled receptor that is highly expressed in invasive cancers. While Thrombin Receptor is known to have important functions in wound healing, by inducing human platelet recruitment to form stable blood clots for vascular injury, its misregulation seems to be intrinsically linked to the formation of invasive and deadly cancers. Thrombin Receptor is important in the cell invasion of cutaneous malignant melanoma, along with its partner KLK6. In lung cancer, Thrombin Receptor migration pairs with ERK1/2 activity to induce cell migration and tumor growth. Thrombin Receptor is known to interact with FAK, which alters endothelial barriers which normally would inhibit cell proliferation across boundaries. It is probably through this relationship that many metastatic effects associated with Thrombin Receptor are compounded. Thrombin Receptor normally functions to assist with healing, particularly in vasculature, but when it is not appropriately regulated, it can catalyze cancer growth and metastasis.

Long Name

Protease-Activated Receptor 1

Alternate Names

Cf2r, F2R, HTR, ThrR, TRGPC

Gene Symbol

F2R

Additional PAR1 Products

Product Documents for PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PAR1/Thrombin Receptor Antibody (N2-11) [DyLight 488]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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