Potassium Channel Kv2.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-261

Novus Biologicals, part of Bio-Techne
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NB300-261
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Key Product Details

Species Reactivity

Rat, Xenopus

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Potassium Channel Kv2.2 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues specific to the Kv2.2 subunit conjugated to KLH. Accession # Q63099

Localization

Cell Membrane

Specificity

Specific for endogenous levels of the ~125 kDa voltage gated potassium channel, Kv2.2 subunit.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

125 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Potassium Channel Kv2.2 Antibody

Western Blot: Potassium Channel Kv2.2 Antibody [NB300-261]

Western Blot: Potassium Channel Kv2.2 Antibody [NB300-261]

Western Blot: Potassium Channel Kv2.2 Antibody [NB300-261] - Rat Brain - The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide block).

Applications for Potassium Channel Kv2.2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000

Immunohistochemistry-Frozen

1:10-1:500

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Potassium Channel Kv2.2

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Alternate Names

KCNB2

Entrez Gene IDs

117105 (Rat)

Gene Symbol

KCNB2

UniProt

Q63099 (Rat)

Additional Potassium Channel Kv2.2 Products

Product Documents for Potassium Channel Kv2.2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Potassium Channel Kv2.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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