Potassium Channel Kv2.2: Proteins and Enzymes

The potassium channel Kv2.2 subunit is a six transmembrane glycoprotein that belongs to the B subgroup of the potassium channel family. It is a voltage- gated channel selective for potassium that helps regulate the electrical properties of smooth muscle cells, various epithelial cell types, and neurons. Specifically it is involved in setting the resting membrane potential and repolarization of the action potential. There are two genes within the Kv2 family (Kv2.1 and Kv2.2) that, although co-expressed, preferentially generate homotetramers rather than heterotetramers.