PSENEN/PEN2 Antibody (6J5O4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16676

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16676-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 6J5O4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PSENEN Antibodies »

Product Specifications

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human PSENEN/PEN2 (NP_758844.1). MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PSENEN/PEN2 Antibody (6J5O4)

Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]

Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]

Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676] - Western blot analysis of extracts of various cell lines, using PSENEN/PEN2 Rabbit mAb (NBP3-16676) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Immunocytochemistry/ Immunofluorescence: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]

Immunocytochemistry/ Immunofluorescence: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]

Immunocytochemistry/Immunofluorescence: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676] - Immunofluorescence analysis of NIH-3T3 cells using PSENEN/PEN2 Rabbit mAb (NBP3-16676) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Applications for PSENEN/PEN2 Antibody (6J5O4)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Western Blot

1:500 - 1:1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PSENEN

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Long Name

Presenilin Enhancer 2 Homolog

Alternate Names

PEN-2

Gene Symbol

PSENEN

Additional PSENEN Products

Product Documents for PSENEN/PEN2 Antibody (6J5O4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PSENEN/PEN2 Antibody (6J5O4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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