PSENEN/PEN2 Antibody (JE41-28)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-75632

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-75632
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JE41-28

Concentration

1 mg/ml

View all PSENEN Antibodies »

Product Specifications

Immunogen

Recombinant protein within Human PSENEN/PEN2 aa 1-101 / 101. (SwissProt: Q9NZ42 Human; SwissProt: Q9CQR7 Mouse; SwissProt: O88777 Rat)

Localization

Cell membrane. Endoplasmic reticulum. Golgi apparatus.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

12 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PSENEN/PEN2 Antibody (JE41-28)

Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632] - Analysis of PEN2 on mouse spleen tissue lysate using anti-PEN2 antibody at 1/2,000 dilution.
Immunocytochemistry/ Immunofluorescence: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Immunocytochemistry/ Immunofluorescence: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Immunocytochemistry/Immunofluorescence: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632] - Staining PEN2 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]

Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632] - Analysis of paraffin-embedded rat cerebellum tissue using anti-PEN2 antibody. Counter stained with hematoxylin.
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Applications for PSENEN/PEN2 Antibody (JE41-28)

Application
Recommended Usage

Flow Cytometry

1:50-1:100

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PSENEN

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Long Name

Presenilin Enhancer 2 Homolog

Alternate Names

PEN-2

Gene Symbol

PSENEN

Additional PSENEN Products

Product Documents for PSENEN/PEN2 Antibody (JE41-28)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PSENEN/PEN2 Antibody (JE41-28)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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