Ryanodine Receptor 2 Antibody (C3-33) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80143B

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP2-80143AF350

Alexa Fluor 405

NBP2-80143AF405

Alexa Fluor 488

NBP2-80143AF488

Alexa Fluor 532

NBP2-80143AF532

Alexa Fluor 594

NBP2-80143AF594

Alexa Fluor 647

NBP2-80143AF647

Alexa Fluor 700

NBP2-80143AF700

Alexa Fluor 750

NBP2-80143AF750

Allophycocyanin

NBP2-80143APC

Allophycocyanin/Cy7

NBP2-80143APCCY7

CoraFluor 1

NBP2-80143CL1

DyLight 350

NBP2-80143UV

DyLight 405

NBP2-80143V

DyLight 488

NBP2-80143G

DyLight 550

NBP2-80143R

DyLight 594

NBP2-80143DL594

DyLight 650

NBP2-80143C

DyLight 680

NBP2-80143FR

DyLight 755

NBP2-80143IR

FITC

NBP2-80143F

HRP

NBP2-80143H

Janelia Fluor 525

NBP2-80143JF525

Janelia Fluor 549

NBP2-80143JF549

Janelia Fluor 646

NBP2-80143JF646

Janelia Fluor 669

NBP2-80143JF669

mFluor Violet 450 SE

NBP2-80143MFV450

mFluor Violet 500 SE

NBP2-80143MFV500

mFluor Violet 610 SE

NBP2-80143MFV610

PE

NBP2-80143PE

PerCP

NBP2-80143PCP

Forumulation

Catalog #

BSA Free

NBP2-80143

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Amphibian, Bovine, Canine, Chicken, Fish, Guinea Pig, Rabbit

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG₁ Clone # C3-33

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Ryanodine Receptor 2 Antibodies »

Product Specifications

Immunogen

Canine cardiac ryanodine receptor (RyR2)

Localization

Membrane; Multi-pass membrane protein

Specificity

Detects Ryanodine Receptor 2. Also shows cross-reactivity with Ryanodine Receptor 1 in amphibian, canine, chicken, fish, guinea pig and rat tissues.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for Ryanodine Receptor 2 Antibody (C3-33) [Biotin]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Ryanodine Receptor 2

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.

Long Name

Ryanodine receptor 2

Alternate Names

hRYR-2, RYR-2, RyR2

Gene Symbol

RYR2

Additional Ryanodine Receptor 2 Products

Product Documents for Ryanodine Receptor 2 Antibody (C3-33) [Biotin]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for Ryanodine Receptor 2 Antibody (C3-33) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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