Serpin E1/PAI-1 Antibody (1D5) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-37532

Novus Biologicals, part of Bio-Techne
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NBP2-37532
NBP2-37532-0.025ml
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1D5

Format

BSA Free

Concentration

1 mg/ml

View all Serpin E1/PAI-1 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human Serpin E1/PAI-1 expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Serpin E1/PAI-1 Antibody (1D5) - BSA Free

Western Blot: Serpin E1/PAI-1 Antibody (1D5)BSA Free [NBP2-37532]

Western Blot: Serpin E1/PAI-1 Antibody (1D5)BSA Free [NBP2-37532]

Western Blot: Serpin E1/PAI-1 Antibody (1D5) [NBP2-37532] - Analysis using SERPINE1 mAb against HEK293 (1) and SERPINE1 (AA: 194-316)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry-Paraffin: Serpin E1/PAI-1 Antibody (1D5) - BSA Free [NBP2-37532]

Immunohistochemistry-Paraffin: Serpin E1/PAI-1 Antibody (1D5) - BSA Free [NBP2-37532]

Immunohistochemistry-Paraffin: Serpin E1/PAI-1 Antibody (1D5) [NBP2-37532] - Analysis of kidney cancer tissues using SERPINE1 mouse mAb with DAB staining.
Flow Cytometry: Serpin E1/PAI-1 Antibody (1D5) - BSA Free [NBP2-37532]

Flow Cytometry: Serpin E1/PAI-1 Antibody (1D5) - BSA Free [NBP2-37532]

Flow Cytometry: Serpin E1/PAI-1 Antibody (1D5) [NBP2-37532] - Analysis of NIH/3T3 cells using SERPINE1 mouse mAb (green) and negative control (red).
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Applications for Serpin E1/PAI-1 Antibody (1D5) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Flow Cytometry

1:200 - 1:400

Immunohistochemistry

1:200 - 1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:500 - 1:2000
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Serpin E1/PAI-1

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

Long Name

Plasminogen Activator Inhibitor

Alternate Names

Nexin, PAI-1, PAI1, PLANH1

Gene Symbol

SERPINE1

Additional Serpin E1/PAI-1 Products

Product Documents for Serpin E1/PAI-1 Antibody (1D5) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Serpin E1/PAI-1 Antibody (1D5) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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